Bianca is
Lorenzo's granddaughter and the two of them live together in Alto Mare. While
Lorenzo was giving
Ash Ketchum and his friends a tour of the temple,
Ash Ketchum saw
Bianca there and quickly chased after her as she left the temple thinking she was the same girl he encountered earlier in the day but at the time he didn't know that Latias was able to transform into human form.
When
Ash Ketchum followed Latias into the Secret Garden,
Bianca's initial reaction what that she thought he was there to get Latios who was attacking him at the time. It wasn't until her grandfather corrected her initial mistake that she apologized to
Ash Ketchum.
Bianca got captured by Zanna and
Oakley while they were attempting to stop them from using the machine in the temple tower.
Ash Ketchum and his friends came to her rescue. She was grateful to them for saving her, her grandfather and Latios.
With the events that had transpired in Alto Mare over,
Ash Ketchum and his friends left but he ended up getting a picture and a kiss from a person that looked like
Bianca but he wasn't sure if it was really her or Latias.