Lyra is the female protagonist from HeartGold and SoulSilver. Her design is loosely based off kris-game, who she replaced.
If chosen as the player character, Lyra sets off on her adventure from New Bark Town with a starter Pokémon from Professor Elm. There, she takes on Johto Gym Leaders, takes down the newly revived Team Rocket, crosses paths with her rival Silver
, and becomes Indigo League Champion. After that, she goes to Kanto, beating the Gym Leaders there too. Finally, she takes on the legend of legends atop Mt. Silver: Red, defeating him. Lyra is the childhood friend of ethan-game. In canon, when she is not chosen, she owns a Marill and is childhood friends of Ethan and Silver.
Lyra appears in Pokémon Masters EX. It's revealed she also was childhood friends with kris-game. Her partner is Chikorita, which can evolve. She also befriends a Jigglypuff.
Pokemon the Series
Lyra meets Ash and his friends just after they rescued her Marill. Hosting a Johto Festa, she invited Ash and his friends to check it out and traveled with him shortly before heading off a journey with Khoury
, who she has a crush on.
Her game self made a cameo in GOTCHA! with the other protagonists.