Alice first met Ash and his friends while she was in her balloon. She noticed that they needed a ride to Álamos Town and she invited them to ride with her. Brock quickly began flirting with her as he does with every girl he sees.
Tonio has a crush on Alice since they were children. Alice fell off a cliff one day while in the garden and Darkrai saved her. When she awoke, she saw Tonio and believed that he saved her.
Alice is able to calm Pokémon by playing Oración, the name of the leaf flute tune that her Grandma taught her. When all the Pokémon in the garden began fighting, she played the song and it calmed them all down.