The 1st opening for the Pocket Monsters Best Wishes Season 2 Episode N uses different lyrics from the song Become an Arrow as the opening for the entire Best Wishes Season 2 series also featured the song.
The opening begins with a darkened scene with a stylistic Reshiram in the background as Satoshi, Pikachu, then Dent and then Iris are shown turning around to face the audience. N makes his appearance by looking up as a flash of light appears and the Pocket Monsters Best Wishes Season 2 Episode N (ポケットモンスター ベストウイッシュ シーズン2 エピソードN) logo appears.
It transitions to the interior of the Aspertia Gym where Cheren is battling Satoshi and Mijumaru with his Herderrier. Dent, Iris, Pikachu and N are above them on a balcony watching the battle.
A scene featuring N on his travels walking and the two Goddesses Concordia and Anthea looking a bit sorrowful as the background has mountainous terrain.
The Rocket Gang returns to the anime in this series and Kojiro is featured in a blue scene, then Musashi with a red scene holding a rose while Nyarth leans against her.
A hand colored picture of the entire Plasma Gang then pans by as it features Ghetsis, Achroma and the Plasma Gang grunts. A rustic looking map of the Isshu region burns away from the center and is replaced with the Plasma Gang logo. Plasma Gang's Lepardas then uses a powerful attack on a skyscrapper from a helicopter and creates a huge explosion as Satoshi and his friends look on and cover themselves after seeing the explosion. A red Genesect appears while its accompanied by four other Genesect as they speed off from the city.
Pikachu is then seen using its Electro Ball and then transitions to Mijumaru using its Aqua Jet to avoid mini explosions around it as it travels down a river. Iris' Kibago is briefly seen using Dragon Rage while Iris' Kairyu takes off into the air with an angry face. Another pan shot featuring Achroma and his Pokémon is shown which is heavily painted in a green and red style. Satoshi's Pikachu and Gantle are then seen fighting Achroma's Pokémon.
Satoshi, Dent, Iris and N are then seen quickly running across a bunch of arches as its destroyed behind them. Handsome and the Rocket Gang then appear on the scene with them to diver the attention of the Plasma Gang. It quickly transitions to a fiery scene with Reshiram and Ghetsis but then colorizes to then show Satoshi and friends along with N looking up at Reshiram. Reshiram attacks them but Satoshi's Lizardon blocks it with Flamethrower and beings to take on Reshiram. The opening then ends with a drawn picture of all the main protagonists and antagonists from the series being looked over by Ghetsis.